Potential Lives Saved (ORS + zinc): Over 640,000 lives saved by 2015 in just four high-burden countries¹
Problem and Proposed Intervention
Pneumonia, diarrhea and malaria remain the three largest killers of children and together account for about 40% of deaths in children under five worldwide.2 An estimated 1.5 million children die each year due to diarrhea alone.2 The majority of these child deaths (60%) occur in just 10 countries: India, Nigeria, Democratic Republic of Congo, Pakistan, Ethiopia, Tanzania, Uganda, Bangladesh, Kenya and Niger. The WHO-recommended treatment for diarrhea is ORS and zinc, products that are highly effective and affordable; ORS and zinc prevent a majority of deaths and costs less than $US 0.50 per treatment course. Zinc, in particular, shortens the duration of acute diarrhea by 25% and treatment failure or death in persistent diarrhea by 40%.3
Despite the existence of this simple, life-saving treatment, many children with diarrhea are not accessing these products in developing countries: only 38% of children receive ORS and less than 5% receive zinc.2 Although zinc, along with ORS, has been recommended by the WHO as the recommended treatment for pediatric diarrhea since 2004, awareness among care-seekers and service providers is limited. In addition, suboptimal products like antibiotics and anti-diarrheals continue to be used. Research and pilot programs have demonstrated success in scaling up ORS and zinc, but have primarily been small-scale. Additional attention and investment in comprehensive and ambitious programs can significantly scale up access to these simple, low-risk products and is essential to accelerating progress to Millennium Development Goal 4 of reducing child mortality by two-thirds by 2015.
Zinc product characteristics:
|Formulation:||20mg scored taste masked dispersible tablet or oral solutions at concentration of 10mg/5ml|
|Dose:||20 mg daily for 10 days (or 10mg daily for 10 days for children >6 months)|
|Avg. Cost:||Approximately US$ 0.31/10 tablets4|
Initial Findings from Product Case Study Working Paper
* Note: The strengths and challenges outlined below are initial findings from a longer working paper developed to analyze the current global situation of each product. The findings are presented below to catalyze further thinking and discussion in order to finalize a list of issues and recommendations. The full working paper texts are forthcoming.
Key issues related to product uptake
Country Context and Diarrhea & Pneumonia Working Group
Recently, there has been growing recognition that additional investment is needed to scale up effective treatment of pneumonia and diarrhea, which has received limited attention and funding to date. Inexpensive treatment is available for these conditions, and significant progress in scaling up treatment coverage can be made, especially in reaching those who currently receive suboptimal medicines. Research and pilot programs have demonstrated effective approaches to scaling-up these treatments. However, these programs are typically small-scale. Comprehensive and ambitious programs designed to build on these initial projects are essential to achieve significant increases in access in the coming years.
In light of this opportunity, a high-level working group has come together to support the 10 high-burden countries (India, Nigeria, Democratic Republic of Congo, Pakistan, Ethiopia, Tanzania, Uganda, Bangladesh, Kenya and Niger) to develop, finance, and implement ambitious plans to scale-up effective treatment for diarrhea and pneumonia. The Initiative, led by UNICEF and the Clinton Health Access Initiative (CHAI), includes the Bill and Melinda Gates Foundation (BMGF), John Snow Inc. (JSI), Population Services International (PSI), the United Nations Secretary General Special Envoy for malaria (UNSE), and the World Health Organization (WHO), among others, and aims to achieve universal access of diarrhea and pneumonia treatment through both the public and private sectors. In order to capitalize on the growing focus on pneumonia and diarrhea, this Initiative started working in the fall of 2011, before the Overlooked Commodities Commission was fully conceptualized and launched.
The Initiative is pursuing multiple, simultaneous efforts at the global and country levels to support the development and implementation of these plans. The timeline for these efforts is ambitious – with the goal of finalizing comprehensive, costed national plans by early 2012. This will allow the execution of plans to begin in 2012, driving towards universal coverage of appropriate treatments for diarrhea and pneumonia in children by 2015 across these 10 focal countries.